A positive injection experience with the Sensoready® Pen

A positive injection experience1*

Deliver high satisfaction with the Sensoready® Pen1†

A positive injection experience1*

Deliver high satisfaction with the Sensoready® Pen1†

Comfortable and patient-friendly device

Easy to operate without assistance1‡

Sensoready® Pen - auto play rotation of the pen plus labeling

In the JUNCTURE study, through 12 weeks1*†:

  • Patients reported nearly no pain and reaction during or after the injection

    • N=182, mean SIAQ score (9.68-9.69) out of 10, with 10 indicating no pain/reaction

  • Each pen contains 150 mg/mL of COSENTYX2

    • Each 300-mg dose is supplied in a carton containing
      two 150-mg/mL Sensoready® Pens

    • Each 150-mg dose is supplied in a carton containing
      one 150-mg/mL Sensoready® Pen

  • Prefilled syringes are also available—each contains 150 mg/mL2

Sensoready® Pen - auto play rotation of the pen plus labeling

The removable cap of the COSENTYX Sensoready® Pen and the prefilled syringe contains natural rubber latex and should not be handled by latex-sensitive individuals. The safe use of the COSENTYX Sensoready® Pen or prefilled syringe in latex-sensitive individuals has not been studied.2

<1% of patients experienced injection site reactions at Week 12

Individual experiences may vary.

*Co-primary end points of the JUNCTURE study were efficacy of COSENTYX vs placebo at Week 12 based on PASI 75 responses and scores of 0 or 1 and a ≥2-grade improvement from baseline on the IGA mod 2011 scale. Secondary end points included usability of the autoinjector, determined by observer rating of successful, hazard-free self-injection, and subject rating of autoinjector acceptability.1

In the JUNCTURE study, satisfaction with self-injection was evaluated in 182 patients using the SIAQ (secondary end point). Responses were scored on a scale of 0 (worst experience) to 10 (best experience), with higher scores indicating a more positive experience. At baseline, the mean score for satisfaction with self-injection was 6.68, and at Week 12, the mean score was 9.03.1

Usability of the autoinjector in the JUNCTURE study was determined by observer rating of successful, hazard-free self-injection and subject rating of autoinjector acceptability. Successful self-administration was defined as subject successfully performing for critical steps as per the IFU. All evaluable subjects (N=178) successfully self-administered treatment at Week 1.1 Ease of use was also evaluated using the SIAQ at Week 12. Scores for the entire cohort ranged from 8.95 to 9.28, indicating excellent subject-reported autoinjector ease of use.1

§Based on safety analysis of 4 pivotal randomized, placebo-controlled trials (N=2399, with n=1382 exposed to any dose of COSENTYX).3

References: 1. Paul C, Lacour JP, Tedremets L, et al; for the JUNCTURE Study Group. Efficacy, safety and usability of secukinumab administration by autoinjector/pen in psoriasis: a randomized, controlled trial (JUNCTURE). J Eur Acad Dermatol Venereol. 2015;29(6):1082-1090. 2. Cosentyx [prescribing information]. East Hanover, NJ: Novartis Pharmaceuticals Corp; January 2020. 3. Data on file. AIN457A Summary of Clinical Safety. Novartis Pharmaceuticals Corp; October 2013.

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IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

COSENTYX is contraindicated in patients with a previous serious hypersensitivity reaction to secukinumab or to any of the excipients in COSENTYX. Cases of anaphylaxis have been reported during treatment with COSENTYX.

WARNINGS AND PRECAUTIONS

Infections

COSENTYX may increase the risk of infections. In clinical trials, a higher rate of infections was observed in COSENTYX treated subjects compared to placebo-treated subjects.

INDICATIONS

COSENTYX® (secukinumab) is indicated for the treatment of moderate to severe plaque psoriasis
in patients 6 years and older who are candidates for systemic therapy or phototherapy.

COSENTYX is indicated for the treatment of adult patients with active psoriatic arthritis.

COSENTYX is indicated for the treatment of adult patients with active ankylosing spondylitis.

INDICATIONS

COSENTYX® (secukinumab) is indicated for the treatment of moderate to severe plaque psoriasis in patients 6 years and older who are candidates for systemic therapy or phototherapy.

COSENTYX is indicated for the treatment of adult patients with active psoriatic arthritis.

COSENTYX is indicated for the treatment of adult patients with active ankylosing spondylitis.

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

COSENTYX is contraindicated in patients with a previous serious hypersensitivity reaction to secukinumab or to any of the excipients in COSENTYX. Cases of anaphylaxis have been reported during treatment with COSENTYX.

WARNINGS AND PRECAUTIONS

Infections

COSENTYX may increase the risk of infections. In clinical trials, a higher rate of infections was observed in COSENTYX treated subjects compared to placebo-treated subjects. In placebo-controlled clinical trials in subjects with moderate to severe plaque psoriasis, higher rates of common infections, such as nasopharyngitis (11.4% versus 8.6%), upper respiratory tract infection (2.5% versus 0.7%) and mucocutaneous infections with candida (1.2% versus 0.3%) were observed with COSENTYX compared with placebo. A similar increase in risk of infection was seen in placebo-controlled trials in subjects with psoriatic arthritis and ankylosing spondylitis. The incidence of some types of infections appeared to be dose-dependent in clinical studies. In the postmarketing setting, serious and some fatal infections have been reported in patients receiving COSENTYX.

Exercise caution when considering the use of COSENTYX in patients with a chronic infection or a history of recurrent infection.

Instruct patients to seek medical advice if signs or symptoms suggestive of an infection occur. If a patient develops a serious infection, monitor the patient closely and discontinue COSENTYX until the infection resolves.

Pre-treatment Evaluation for Tuberculosis

Evaluate patients for tuberculosis (TB) infection prior to initiating treatment with COSENTYX. Avoid administration of COSENTYX to patients with active TB infection. Initiate treatment of latent TB prior to administering COSENTYX. Consider anti-TB therapy prior to initiation of COSENTYX in patients with a past history of latent or active TB in whom an adequate course of treatment cannot be confirmed. Monitor patients closely for signs and symptoms of active TB during and after treatment.

Inflammatory Bowel Disease

Caution should be used when prescribing COSENTYX to patients with inflammatory bowel disease. Exacerbations, in some cases serious, occurred in COSENTYX treated subjects during clinical trials in plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis. In addition, new onset inflammatory bowel disease cases occurred in clinical trials with COSENTYX. In an exploratory trial in 59 subjects with active Crohnís disease, there were trends toward greater disease activity and increased adverse events in the secukinumab group as compared to the placebo group. Patients who are treated with COSENTYX should be monitored for signs and symptoms of inflammatory bowel disease.

Hypersensitivity Reactions

Anaphylaxis and cases of urticaria occurred in COSENTYX treated subjects in clinical trials. If an anaphylactic or other serious allergic reaction occurs, administration of COSENTYX should be discontinued immediately and appropriate therapy initiated.

The removable caps of the COSENTYX Sensoready® pen and the COSENTYX 1 mL and 0.5 mL prefilled syringes contain natural rubber latex, which may cause an allergic reaction in latex-sensitive individuals. The safe use of the COSENTYX Sensoready pen or prefilled syringe in latex-sensitive individuals has not been studied.

Immunizations

Prior to initiating therapy with COSENTYX, consider completion of all age appropriate immunizations according to current immunization guidelines. COSENTYX may alter a patientís immune response to live vaccines. Avoid use of live vaccines in patients treated with COSENTYX.

MOST COMMON ADVERSE REACTIONS

Most common adverse reactions (>1%) are nasopharyngitis, diarrhea, and upper respiratory tract infection.

Please see full Prescribing Information, including Medication Guide.